Application of molecularly imprinted technology for separation of PGG from Guizhi Fuling capsule / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1012-1016, 2015.
Article
em Zh
| WPRIM
| ID: wpr-246160
Biblioteca responsável:
WPRO
ABSTRACT
1,2,3,4,6-penta-O-galloyl-D-glucose (PGG) is one of the main active compounds of Guizhi Fuling capsule. Molecularly imprinted polymers (MIP) have high affinity toward template molecules synthesized by molecularly imprinted technology for its specific combined sites, which can overcome the shortcoming of traditional separation methods, such as complex operation, low efficiency, using large quantity of solvent and environmental pollution. In this paper, surface molecularly imprinted polymer (SMIP) was prepared by surface imprinting with PGG as the template molecule. Its adsorption capacity was measured by the scatchard equation. The separation of PGG from Guizhi Fuling capsule at preparatived scale was achieved with molecularly imprinted polymer as stationary phase and the purity was 90.2% by HPLC. This method can be used to prepare PGG from Guizhi Fuling capsule with large capacity and is easy to operate. It provides a new method for efficient separation and purification for other natural products.
Texto completo:
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Índice:
WPRIM
Assunto principal:
Polímeros
/
Cápsulas
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Medicamentos de Ervas Chinesas
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Química
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Cromatografia Líquida de Alta Pressão
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Adsorção
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Taninos Hidrolisáveis
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Impressão Molecular
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2015
Tipo de documento:
Article