Melanocortin-4 receptor expression in the cuneiform nucleus is involved in modulation of opioidergic signaling / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences)
; (6): 662-665, 2015.
Article
em En
| WPRIM
| ID: wpr-250362
Biblioteca responsável:
WPRO
ABSTRACT
Substantial evidence has suggested that deep brain stimulation of the cuneiform nucleus has become a remarkable treatment option for intractable pain, but the possible mechanism is poorly understood. Using a melanocortin-4 receptor (MC4R)-green fluorescent protein (GFP) reporter knockin mouse, we showed that a large number of MC4R-GFP-positive neurons were expressed in the cuneiform nucleus. Immunofluorescence revealed that approximately 40%-50% of MC4R-GFP-positive neurons expressed mu opioid receptors, indicating that they were opioidergic signaling. Our findings support the hypothesis that MC4R expression in the cuneiform nucleus is involved in the modulation of opioidergic signaling.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Proteínas Recombinantes de Fusão
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Camundongos Transgênicos
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Transdução de Sinais
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Regulação da Expressão Gênica
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Genes Reporter
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Receptores Opioides mu
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Biologia Celular
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Receptor Tipo 4 de Melanocortina
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Proteínas de Fluorescência Verde
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Técnicas de Introdução de Genes
Limite:
Animals
Idioma:
En
Revista:
Journal of Huazhong University of Science and Technology (Medical Sciences)
Ano de publicação:
2015
Tipo de documento:
Article