Design, synthesis of quinolinone acid-containing compounds with anti-HIV integrase activity / 药学学报
Acta Pharmaceutica Sinica
; (12): 263-267, 2010.
Article
em Zh
| WPRIM
| ID: wpr-250632
Biblioteca responsável:
WPRO
ABSTRACT
A series of novel quinolinone acid-containing compounds were designed and synthesized. Their structures were confirmed with 1H NMR and MS. The target compounds were tested for anti-HIV-1 integrase activities in vitro with enzyme linked immunosorbent assay (ELISA). The result showed that D-2, D-4 and D-7 have anti-integrase activity with IC50 < 100 micromol L(-1).
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Farmacologia
/
Relação Estrutura-Atividade
/
Química
/
Quinolonas
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Inibidores de Integrase de HIV
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Integrase de HIV
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Concentração Inibidora 50
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Metabolismo
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2010
Tipo de documento:
Article