The aquation of oxaliplatin and the effect of acid / 药学学报
Acta Pharmaceutica Sinica
; (12): 223-226, 2003.
Article
em Zh
| WPRIM
| ID: wpr-251137
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To investigate the aquation of oxaliplatin in aqueous solution at different temperatures and gain the kinetic data.</p><p><b>METHODS</b>Electronic conductometry and high performance liquid chromatography (HPLC) were used to measure the oxaliplatin content in the reaction systems at different time.</p><p><b>RESULTS</b>The aquation of oxaliplatin followed a pseudo-first-order rate law. In the absence of H+, the observed rate constant kobs was 7.76 x 10(-6).min-1 and the half life t1/2 was 62 days at 25 degrees C. In the presence of H+, the aquation could be accelerated by H+ according to the equation kobs = (2.61 + 21.9 [H+]) x 10(-4).min-1. The mechanism of aquation has also been proposed in this paper. From the mechanism, the rate of aquation following to r = (k1 k2) [l-OHP]/k-1 in the absence of H+ and r = (k1 + K0k3 [H+]) [l-OHP] in the presence of H+ have been deduced, which were in perfect agreement with the experimental results.</p><p><b>CONCLUSION</b>In the absence of H+, the aqueous solution of oxaliplatin is stable, which meets to the request of clinical.</p>
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Índice:
WPRIM
Assunto principal:
Compostos Organoplatínicos
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Soluções
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Ácidos
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Água
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Cinética
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Química
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Cromatografia Líquida de Alta Pressão
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Concentração de Íons de Hidrogênio
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Antineoplásicos
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2003
Tipo de documento:
Article