Association of nitric oxide and eNOS with the pathogenesis of vasovagal syncope / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 478-480, 2008.
Article
em Zh
| WPRIM
| ID: wpr-252041
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the roles of nitric oxide (NO) and eNOS in the pathogenesis of vasovagal syncope (VVS).</p><p><b>METHODS</b>Fourteen children with VVS (group A), 10 children with syncope other than vasovagal (group B) and 20 healthy volunteers (group C) were enrolled. Plasma NO levels in groups A and B were determined before and at the termination of the head-up tilt table test (HUT). The G894T polymorphism within the eNOS gene was determined in the three groups.</p><p><b>RESULTS</b>Plasma NO levels in group A increased significantly when syncope attacked from 76.7+/-9.6 micromol/L (before HUT) to 90.0+/-11.4 micromol/L (P<0.05). After the syncope attack was improved, plasma NO level in group A was significantly reduced. There were no statistical differences in plasma NO levels before and after the HUT in group B. Determining the G894T polymorphism within the eNOS gene showed that group A was associated with a higher incidence of the GT gene type as compared to groups B and C (42.9% vs 10%; P<0.05).</p><p><b>CONCLUSIONS</b>Plasma NO may be involved in the pathogenesis of VVS. The increased plasma NO level may be associated with the G894T polymorphism of the eNOS gene.</p>
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Índice:
WPRIM
Assunto principal:
Fisiologia
/
Polimorfismo Genético
/
Sangue
/
Síncope Vasovagal
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Óxido Nítrico Sintase Tipo III
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Genética
/
Óxido Nítrico
Tipo de estudo:
Etiology_studies
Limite:
Child
/
Humans
Idioma:
Zh
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2008
Tipo de documento:
Article