The effect of angiotensin-(1-7) on the mRNA expression of PDGF and TGF-beta1 in the kidney of diabetic rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 475-478, 2008.
Article
em Zh
| WPRIM
| ID: wpr-252736
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WPRO
ABSTRACT
<p><b>AIM</b>To study the effect of angiotensin-(1-7) on the kidney of diabetic rats by observing the mRNA expression of PDGF and TGF-beta1.</p><p><b>METHODS</b>SD rats were divided into three groups Group C (uni-nephrectomy control group), Group D (diabetic model control group), Group T (Ang-(1-7) treated group). We evaluated blood glucose,urea nitrogen, creatinine and urine albumin excretion respectively, studied the renal morphology by light microscope, and detected the gene expression of PDGF, TGF-beta1 in renal tissue by RT-PCR technique.</p><p><b>RESULTS</b>There was significant difference between the group D and T about the RW/BW, renal morphology, the total urine protein and the mRNA expression of PDGF and TGF-beta1.</p><p><b>CONCLUSION</b>Ang-(1-7) can relieve the renal process of diabetic rats.</p>
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Índice:
WPRIM
Assunto principal:
Patologia
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Fragmentos de Peptídeos
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Farmacologia
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Fator de Crescimento Derivado de Plaquetas
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RNA Mensageiro
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Angiotensina I
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Ratos Sprague-Dawley
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Diabetes Mellitus Experimental
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Nefropatias Diabéticas
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Fator de Crescimento Transformador beta1
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2008
Tipo de documento:
Article