Single nucleotide polymorphism of interferon-gamma gene +874 T/A in patients with aplastic anemia / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 325-327, 2008.
Article
em Zh
| WPRIM
| ID: wpr-253326
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WPRO
ABSTRACT
The aim of this study was to investigate whether the single nucleotide polymorphism (SNP) of interferon-gamma (IFN-gamma) +874 T/A correlates with aplastic anemia. Amplification refractory mutation system-polymerase chain reaction was used to amplify the polymorphism gene segment of IFN-gamma +874 A/T from 54 aplastic anemia patients and 51 healthy adults. The results showed that the frequency of IFN-gamma +874 TT genotype and T allele was significantly higher in patients with aplastic anemia than that in the healthy adults (42.6% vs 17.6%, chi2=13.780, p=0.01; 65.7% vs 39.2%; chi2=14.811, p<0.001). In conclusion, IFN-gamma +874 A/T gene polymorphism is correlated with the susceptibility of aplastic anemia, but not significantly correlated with the the severity of aplastic anemia.
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Índice:
WPRIM
Assunto principal:
Dados de Sequência Molecular
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Sequência de Bases
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Interferon gama
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Predisposição Genética para Doença
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Polimorfismo de Nucleotídeo Único
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Alelos
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Genética
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Genótipo
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Anemia Aplástica
Limite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Ano de publicação:
2008
Tipo de documento:
Article