Polarographic behavior and determination of glimepiride / 药学学报
Acta Pharmaceutica Sinica
; (12): 750-753, 2005.
Article
em Zh
| WPRIM
| ID: wpr-253575
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To establish a polarographic method of parallel catalytic hydrogen wave for determination of glimepiride.</p><p><b>METHODS</b>The catalytic wave of glimepiride in the presence of K2S2O8 was used to improve the analytical sensitivity. The rapid determination of glimepiride was done by linear single sweep polarography.</p><p><b>RESULTS</b>The catalytic hydrogen wave of glimepiride was measured at ca. -1.36 (vs SCE) in 0.09 mol x L(-1) Na2B4O7-KH2PO4 (pH 6.24 +/- 0.1) supporting electrolyte. When 1.0 x 10(-2) mol x L(-1) K2S2O8 was present, the current increased by 25 times, and the peak potentioal was unchanged, producing a more sensitive parallel catalytic hydrogen wave. The peak current of the parallel catalytic hydrogen wave was rectilinear to the glimepiride concentration in the range 1.0 x 10(-7) - 4.2 x 10(-5) mol x L(-1) (r = 0.9990, n = 9). The detection limit was 5.0 x 10(-8) mol x L(-1).</p><p><b>CONCLUSION</b>The proposed method could be applied to the determination of glimepiride in pharmaceuticals without preliminary separation.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Polarografia
/
Sulfatos
/
Compostos de Sulfonilureia
/
Urina
/
Catálise
/
Compostos de Potássio
/
Hipoglicemiantes
/
Métodos
Limite:
Humans
/
Male
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2005
Tipo de documento:
Article