Expression and significance of PCNA and p27 in benign prostate hypertrophy and prostate carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 476-478, 2004.
Article
em Zh
| WPRIM
| ID: wpr-254290
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of PCNA and p27 in human benign prostate hypertrophy (BPH) and prostate carcinoma (PCa) and their effect on the genesis and progression of the tumor.</p><p><b>METHODS</b>The paraffin-embedded sections of 30 cases with BPH and 37 cases with PCa were collected. The expression of p27 and PCNA protein were examined by S-P immunohistochemical method. Comparative analysis for BPH and pathological grade and clinical stage of PCa was performed.</p><p><b>RESULTS</b>The expression of PCNA in BPH (3.3%) was significantly lower than that in Pca (83.8%, P < 0.01). The expression of p27 in BPH (70.0%) was significantly higher than that in Pca (27.0%, P < 0.05). The expression of p27 was not correlated with histological grade and clinical stage in Pca (P > 0.05). An inverse correlation was found between p27 and PCNA expression in BPH (P < 0.01), while no correlation was found in Pca (P > 0.05).</p><p><b>CONCLUSION</b>The loss or decreased expression of p27 protein may be related to the genesis of benign prostate hypertrophy, but not to the development of prostate carcinoma; the overexpression of PCNA may play an important role in the malignant behavior and progression of prostate carcinoma.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Patologia
/
Prognóstico
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Hiperplasia Prostática
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Neoplasias da Próstata
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Adenocarcinoma
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Regulação Neoplásica da Expressão Gênica
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Genes Supressores de Tumor
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Antígeno Nuclear de Célula em Proliferação
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Proteínas de Ciclo Celular
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Proteínas Supressoras de Tumor
Tipo de estudo:
Prognostic_studies
Limite:
Aged
/
Aged80
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Oncology
Ano de publicação:
2004
Tipo de documento:
Article