Association of interleukin 10 gene -592C/A polymorphism with coronary artery disease / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To assess the association of interleukin 10 (IL10) gene -592C/A polymorphism with morbidity of coronary heart disease in a southern Chinese Han population.</p><p><b>METHODS</b>Frequencies of various genotypes and alleles for the IL10 -592C/A polymorphism (rs1800872) were determined by the means of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) in 249 patients and 132 unaffected controls.</p><p><b>RESULTS</b>The frequencies of both IL10 -592C/A site and different alleles have reached statistical significance (P<0.05) after correcting the difference in clinical data by logistic regression analysis. The risk of coronary heart disease in the patients with A gene (AA+CA) was 2.449 times greater than those without (95%CI:1.214-4.940, P=0.012).</p><p><b>CONCLUSION</b>IL10 gene -592C/A polymorphism is associated with the risk of coronary heart disease. Allele A may be a risk factor for this disease in the studied population.</p>