Therapeutic effect of zinc sulfate on lung injury during superior mesenteric artery occlusion(SMAO) shock / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 90-93, 2006.
Article
em Zh
| WPRIM
| ID: wpr-254597
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To study preventive and therapeutic effect of zinc sulfate on lung injury during superior mesenteric artery occlusion (SMAO) shock and their mechanism of action.</p><p><b>METHODS</b>Model of rabbit SMAO shock was made. The effect of zinc sulfate on the malondialdehyde (MDA) in erythrocyte membrane and plasma, oxidase (XOD) in plasma, superoxide dismutase (SOD) in erythrocyte and MDA, SOD and pulmonary surfactant (PS) in lung tissues homogenate were observed.</p><p><b>RESULTS</b>The administration of zinc sulfate decreased MDA and XOD, prevented the reduction of SOD and PS, and alleviated lung injury.</p><p><b>CONCLUSION</b>It is suggested that lung is injured during SMAO shock and zinc sulfate possesses preventive and therapeutic effect, through stabilized membrane.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Patologia
/
Choque
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Artéria Mesentérica Superior
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Sulfato de Zinco
/
Usos Terapêuticos
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Tratamento Farmacológico
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Lesão Pulmonar
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Pulmão
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Oclusão Vascular Mesentérica
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Metabolismo
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2006
Tipo de documento:
Article