Therapeutic effect of zinc sulfate on lung injury during superior mesenteric artery occlusion(SMAO) shock / 中国应用生理学杂志

ABSTRACT

<p><b>AIM</b>To study preventive and therapeutic effect of zinc sulfate on lung injury during superior mesenteric artery occlusion (SMAO) shock and their mechanism of action.</p><p><b>METHODS</b>Model of rabbit SMAO shock was made. The effect of zinc sulfate on the malondialdehyde (MDA) in erythrocyte membrane and plasma, oxidase (XOD) in plasma, superoxide dismutase (SOD) in erythrocyte and MDA, SOD and pulmonary surfactant (PS) in lung tissues homogenate were observed.</p><p><b>RESULTS</b>The administration of zinc sulfate decreased MDA and XOD, prevented the reduction of SOD and PS, and alleviated lung injury.</p><p><b>CONCLUSION</b>It is suggested that lung is injured during SMAO shock and zinc sulfate possesses preventive and therapeutic effect, through stabilized membrane.</p>