Expression of vacuole membrane protein 1 and its prognostic value in invasive ductal carcinoma of the breast / 中华病理学杂志
Chinese Journal of Pathology
; (12): 86-89, 2013.
Article
em Zh
| WPRIM
| ID: wpr-256247
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ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of vacuole membrane protein 1 (Vmp1) and its prognostic value in invasive ductal carcinoma (IDC) and concomitant ductal carcinoma in situ (DCIS) of the breast.</p><p><b>METHODS</b>The expression and location of Vmp1 in the breast tissues from 102 patients with IDC and 32 concomitant DCIS were detected by immunohistochemical SP method, and the relationship with clinicopathologic parameters was analyzed.</p><p><b>RESULTS</b>Vmp1 expression was observed in the cytoplasm of the cancer cells in 57.8% (59/102) cases, and correlated with grade (χ(2) = 12.644, P = 0.002), pTNM stage (χ(2) = 11.987, P = 0.001), node status (χ(2) = 9.341, P = 0.002), tumor diameter (χ(2) = 7.630, P = 0.022) as well as Nottingham Prognostic Index (NPI;χ(2) = 15.561, P = 0.000). The expression of Vmp1 in concomitant DCIS was higher than that in IDC (81.3% vs 56.3%; χ(2) = 4.655, P = 0.031). In this cohort, the mean disease-free survival was 81.2 months; the 5-year overall survival rate was 90.2% (92/102) and the disease-free survival rate was 81.4% (83/102). Vmp1 expression had significant influence on disease-free survival time, with Vmp1-negative patients showing poor prognosis (χ(2) = 11.192, P = 0.001). COX's proportional hazards regression model revealed that Vmp1 was a protective factor, with relative risk < 1.</p><p><b>CONCLUSIONS</b>The detection of Vmp1 in IDC may be helpful for prognosis prediction; the patients with Vmp1 expression may have a better prognosis.</p>
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Assunto principal:
Patologia
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Cirurgia Geral
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Neoplasias da Mama
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Modelos de Riscos Proporcionais
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Taxa de Sobrevida
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Seguimentos
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Carcinoma Ductal de Mama
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Carcinoma Intraductal não Infiltrante
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Intervalo Livre de Doença
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Gradação de Tumores
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
Idioma:
Zh
Revista:
Chinese Journal of Pathology
Ano de publicação:
2013
Tipo de documento:
Article