Lipopolysaccharide affects male reproductive function through Toll-like receptors / 中华男科学杂志
National Journal of Andrology
; (12): 163-168, 2013.
Article
em Zh
| WPRIM
| ID: wpr-256942
Biblioteca responsável:
WPRO
ABSTRACT
Reproductive tract infection is one of the factors of male infertility, but the mechanisms responsible are hitherto poorly defined. Recent studies show that one of the microbial pattern-recognition receptors, Toll-like receptor (TLR) signaling pathway, plays a critical role in inflammation-induced male infertility. Lipopolysaccharide (LPS), a major component in the cell wall of gram-negative bacteria, could induce inflammatory response through TLRs. A large number of researches suggest that TLRs express widely in the male reproductive tract and LPS-induced inflammatory reaction through TLRs may affect male fertility. This article presents an overview on how LPS-induced inflammation through TLRs affects male fertility in terms of its influence on the testis, epididymis and sperm quality.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Patologia
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Lipopolissacarídeos
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Receptores Toll-Like
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Doenças dos Genitais Masculinos
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Bactérias Gram-Negativas
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Infertilidade Masculina
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Inflamação
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Metabolismo
Limite:
Humans
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Male
Idioma:
Zh
Revista:
National Journal of Andrology
Ano de publicação:
2013
Tipo de documento:
Article