Association between tartrate-resistant acid phosphatase 5 gene polymorphism and adolescent idiopathic scoliosis / 中华外科杂志
Chinese Journal of Surgery
; (12): 66-69, 2012.
Article
em Zh
| WPRIM
| ID: wpr-257551
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WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate whether the titrate-resistant acid phosphatase 5 (ACP5) gene polymorphisms were associated with the occurrence or curve severity of adolescent idiopathic scoliosis (AIS).</p><p><b>METHODS</b>There were 372 AIS patients from January 2006 to December 2008 and 239 normal controls from March 2005 to August 2006 were recruited. The Cobb angles were ≥ 10° in all AIS patients. Using the haplotype data of Han population from the Hapmap Project, two tag SNPs (rs2229531, rs2071484) were defined for ACP5 gene. PCR-restriction fragment length polymorphism was used for the genotyping.</p><p><b>RESULTS</b>No polymorphism in rs2229531 was found in this study. The genotype and allele frequency distribution in rs2071484 were similar between AIS patients and normal controls (χ(2) = 3.336 and 1.438, P > 0.05). The mean maximum Cobb angles of different genotypes of rs2071484 in ACP5 gene were 38° ± 19° in AA, 34° ± 14° in AG and 38° ± 21° in GG, which were similar with each other among AIS patients who reached skeletal maturity or received surgery treatment (P = 0.157).</p><p><b>CONCLUSION</b>The ACP5 gene is neither associated with the occurrence nor the curve severity of AIS.</p>
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Índice:
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Assunto principal:
Polimorfismo Genético
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Escoliose
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Fosfatase Ácida
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Fosfatase Ácida Resistente a Tartarato
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Genética
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Isoenzimas
Limite:
Adolescent
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Child
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Surgery
Ano de publicação:
2012
Tipo de documento:
Article