Roles of TRESK, a novel two-pore domain K+ channel, in pain pathway and general anesthesia / 神经科学通报·英文版
Neuroscience Bulletin
; (6): 166-172, 2008.
Article
em En
| WPRIM
| ID: wpr-264680
Biblioteca responsável:
WPRO
ABSTRACT
TRESK is the most recently reported two-pore domain K+ channel, and different from other two-pore domain channels in gene, molecular structure, electrophysiological and pharmacological properties. Although the current knowledge of this potassium channel is inadequate, researches have demonstrated that TRESK is remarkablely linked to acute and chronic pain by activation of calcineurin. The fact that TRESK is sensitive to volatile anesthetics and localization in central nerve system implies that TRESK may play a very important role in the mechanism mediating general anesthesia. The further research of TRESK may contribute to explore the underlying mechanism of some pathological conditions and yield novel treatments for some diseases.
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1
Índice:
WPRIM
Assunto principal:
Dor
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Farmacologia
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Fisiologia
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Canais de Potássio
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Membrana Celular
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Sistema Nervoso Central
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Química
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Sequência de Aminoácidos
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Sistema Nervoso Periférico
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Anestésicos Gerais
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Neuroscience Bulletin
Ano de publicação:
2008
Tipo de documento:
Article