Migraine as a sex-conditioned inherited disorder: evidences from China and the world / 神经科学通报·英文版
Neuroscience Bulletin
; (6): 110-116, 2008.
Article
em En
| WPRIM
| ID: wpr-264688
Biblioteca responsável:
WPRO
ABSTRACT
Migraine is a complex and heterogeneous disorder. Although several genetic models has been proposed including autosomal-dominant/autosomal recessive, sex-linked, sex-limited, mitochondrial, and multi-gene, none of these models can well-explain the transmission of the disease. We hypothesied that migraine is a sex-conditioned inherited disorder (autosomal dominant in females and autosomal recessive in males). This hypothesis is supported by the evidence such as the locations of genes associated with familial hemiplegic migraine, possibly "typical" migraine as well (dominantly on chromosome 19p, 1q, and 2q), male:female ratio of prevalence (1:2-1:4), the mostly youth-onset, the provocation by the contraceptives, the induction by menstruation, and the self-limitation after menopause. Female sex-hormones appear to be the key contributor to a higher prevalence of migraine in female. Socio-environmental factors may also play an important role.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Hormônios Esteroides Gonadais
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China
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Fatores Sexuais
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Epidemiologia
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Idade de Início
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Predisposição Genética para Doença
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Padrões de Herança
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Genes Dominantes
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Genética
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Ciclo Menstrual
Tipo de estudo:
Prognostic_studies
Limite:
Female
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Humans
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Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Neuroscience Bulletin
Ano de publicação:
2008
Tipo de documento:
Article