TRAIL gene polymorphism and genetic susceptibility to prostate cancer in the Chinese Han population of Nanjing / 中华男科学杂志
National Journal of Andrology
; (12): 242-246, 2011.
Article
em Zh
| WPRIM
| ID: wpr-266183
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation between the polymorphism of the tumor necrosis factor-related apoptosis inducing ligand (TRAIL) and the genetic susceptibility to prostate cancer (PCa) in the Chinese Han population in Nanjing.</p><p><b>METHODS</b>We performed a case control study on 187 cases of PCa and 237 cancer-free healthy controls. Peripheral blood genome DNA was extracted from the subjects for analysis of the polymorphism of the TRAIL-716 locus by polymerase chain reaction-ligase detection reaction (PCR-LDR). The correlations between the susceptibility to PCa and different genotypes were compared.</p><p><b>RESULTS</b>An SNP (-716A/G) was found in the promoter of the TRAIL gene. AA, AG and GG genotypes were identified. Logistic regression analysis suggested that AG, GG and AG + GG genotypes had no significant correlation with the risk of PCa (OR = 0.89, 95% CI = 0.54 -1.47; OR = 0.94, 95% CI = 0.69 -1.27; OR = 0.87, 95% CI = 0.54 - 1.41).</p><p><b>CONCLUSION</b>The TRAIL-716 polymorphism is not directly related with the genetic susceptibility to PCa in the Chinese Han population of Nanjing.</p>
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Índice:
WPRIM
Assunto principal:
Neoplasias da Próstata
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Estudos de Casos e Controles
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China
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Predisposição Genética para Doença
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Polimorfismo de Nucleotídeo Único
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Povo Asiático
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Ligante Indutor de Apoptose Relacionado a TNF
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Genética
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Genótipo
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Humans
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Male
País/Região como assunto:
Asia
Idioma:
Zh
Revista:
National Journal of Andrology
Ano de publicação:
2011
Tipo de documento:
Article