Effects of electroacupuncture on CRH, IL-2 and beta-EP contents in the hypothalamus in the rat of adjuvant arthritis / 中国针灸
Chinese Acupuncture & Moxibustion
; (12): 793-796, 2005.
Article
em Zh
| WPRIM
| ID: wpr-267326
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore Mechanisms of electroacupuncture in anti-inflammation and immunoregulation, and to compare differences among "Dazhui" (GV 14), "Mingmen "(GV 4) and non-acupoint in these actions.</p><p><b>METHODS</b>Adjuvant arthritis rat model was made. The rats were divided into 5 groups normal group, model group, "Dazhui" (GV 14) electroacupuncture group, "Mingmen" (GV 4) electroacupuncture group and non-acupoint electroacupuncture group. Effects of electroacupuncture on local joint inflammation and corticotropin-releasing hormone (CRH), beta-endorphin (betaEP) and interleukin-2 (IL-2) contents in the hypothalamus were observed and differences of the actions among different points were compared.</p><p><b>RESULTS</b>CRH content in the hypothalamus in the "Dazhui" (GV 14) electroacupuncture group decreased as compared with the model group (P < 0.05); there was no significant change in beta-EP and IL-2 contents of the hypothalamus in the 3 electroacupuncture groups as compared with the model group (P > 0.05); there was positive correlation between CRH and IL-2 contents, and between IL-2 and beta-EP contents in the hypothalamus. The swelling rate of the toe in the "Dazhui" (GV 14) group and the "Mingmen" (GV 4) group was lower than that in the non-acupoint group (P < 0 05).</p><p><b>CONCLUSION</b>Electroacupuncture exerts anti-inflammation and immunoregulation possibly via regulation of CRH, IL-2 and beta-EP each other, and the anti-inflammation action of "Dazhui" (GV 14) and "Mingmen" (GV 4) is stronger than that of non-acupoint.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Artrite Experimental
/
Pontos de Acupuntura
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Eletroacupuntura
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Interleucina-2
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Hipotálamo
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
Zh
Revista:
Chinese Acupuncture & Moxibustion
Ano de publicação:
2005
Tipo de documento:
Article