Proton magnetic resonance spectroscopic imaging of the hippocampus in schizophrenia patients before and after surgery / 南方医科大学学报
Journal of Southern Medical University
; (12): 996-998, 2009.
Article
em Zh
| WPRIM
| ID: wpr-268789
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the features of proton magnetic resonance spectroscopy (1H-MRS) of the hippocampus in schizophrenia patients before and after stereotactic neurosurgery.</p><p><b>METHODS</b>1H-MRS was performed to determine NAA/Cr and CHO/Cr ratios on the bilateral hippocampal regions before and after stereotactic neurosurgery in 20 schizophrenia patients, with 20 healthy individuals as the controls.</p><p><b>RESULTS</b>The NAA/Cr ratio in the hippocampal regions was significantly lower and the CHO/Cr ratio significantly higher in schizophrenia patients before the surgery than in the healthy controls (P<0.01). The NAA/Cr and CHO/Cr ratios in the hippocampal regions underwent no significant changes in the patients after the surgeries (P>0.05).</p><p><b>CONCLUSION</b>Neuronal and cell membrane metabolism impairment is present in the hippocampus of schizophrenia patients, and stereotactic neurosurgery does not produce obvious adverse effects on the cell membrane metabolism in the hippocampus of the patients.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Patologia
/
Prótons
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Esquizofrenia
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Cirurgia Geral
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Espectroscopia de Ressonância Magnética
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Estudos de Casos e Controles
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Colina
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Técnicas Estereotáxicas
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Ácido Aspártico
/
Creatina
Tipo de estudo:
Observational_studies
Limite:
Adolescent
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Adult
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Female
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Humans
/
Male
Idioma:
Zh
Revista:
Journal of Southern Medical University
Ano de publicação:
2009
Tipo de documento:
Article