Allogeneic leukocyte immunization combined with IVF-ET for treatment of infertility induced by recurrent spontaneous abortion / 南方医科大学学报
Journal of Southern Medical University
; (12): 1300-1301, 2008.
Article
em Zh
| WPRIM
| ID: wpr-270154
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of allogeneic leukocyte immunization combined with in vitro fertilization-embryo transfer (IVF-ET) for treatment of infertility induced by habitual abortion.</p><p><b>METHODS</b>Allogeneic leukocyte immunization was performed in 9 patients with infertility induced by habitual abortion, with another 9 patients undergoing IVF-ET without habitual abortion as the control group. All the patients were treated with long GnRH-a protocols. The infertility patients with recurrent spontaneous abortion history were immunized with lymphocytes from the husband for before IVF-ET and after clinical pregnancy.</p><p><b>RESULTS</b>The fertilization rates of the immunotherapy group and control group were 81.3% and 82.2%, respectively, showing no significant difference (P>0.05). Five patients in each group had clinical pregnancy, and a twin pregnancy occurred in the control group. The embryo implantation rates were also comparable between the two groups (22.7% vs 28.6%, P>0.05). All the fetuses resulted from IVF-ET developed normally and were healthily delivered.</p><p><b>CONCLUSION</b>Allogeneic leukocyte immunotherapy along with IVF-ET is effective for treatment of infertility resulting from recurrent spontaneous abortion.</p>
Texto completo:
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Índice:
WPRIM
Assunto principal:
Terapêutica
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Resultado da Gravidez
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Fertilização in vitro
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Aborto Habitual
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Resultado do Tratamento
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Transferência Adotiva
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Transferência Embrionária
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Infertilidade Feminina
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Métodos
Tipo de estudo:
Guideline
Limite:
Adult
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Female
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Humans
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Pregnancy
Idioma:
Zh
Revista:
Journal of Southern Medical University
Ano de publicação:
2008
Tipo de documento:
Article