Injection of saline into unilateral central piriform cortex inhibits amygdaloid-kindled seizures in rats / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 141-145, 2007.
Article
em Zh
| WPRIM
| ID: wpr-271560
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of microinjection of saline into unilateral central piriform cortex (cPC) on the generalized seizures in amygdaloid-kindled rats.</p><p><b>METHODS</b>Different volumes of saline were injected into the right or left cPC of amygdaloid-kindled rats, and its effect on generalized seizures was observed.</p><p><b>RESULT</b>Saline injection at different volumes 0.1 microl, 0.25 microl and 1 microl) significantly decreased the incidence and duration of generalized seizures (P<0.05), the anticonvulsant effect lasted for up to 10 d. In addition, 10 min after ipsilateral injection of saline the generalized seizure thresholds were significantly increased; while this effect was observed 30 min later when contralateral injection was used.</p><p><b>CONCLUSION</b>Unilateral saline injection into cPC has a significant anticonvulsant effect, which might be used for treatment of human temporal lobe epilepsy in the future.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Cloreto de Sódio
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Córtex Cerebral
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Epilepsia Generalizada
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Ratos Sprague-Dawley
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Estimulação Elétrica
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Tonsila do Cerebelo
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Excitação Neurológica
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Metabolismo
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Microinjeções
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Anticonvulsivantes
Limite:
Animals
Idioma:
Zh
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2007
Tipo de documento:
Article