Levels of TNF-α, IL-6 and IL-10 in bronchoalveolar lavage fluid in children with Mycoplasma pneumoniae pneumonia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 808-810, 2011.
Article
em Zh
| WPRIM
| ID: wpr-272464
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the levels and roles of cytokines TNF-α, IL-6 and IL-10 in bronchoalveolar lavage fluid (BALF) in children with Mycoplasma pneumoniae pneumonia (MPP).</p><p><b>METHODS</b>The levels of TNF-α, IL-6 and IL-10 in BALF were measured using ELISA in children with MPP at acute stage (n=45) and at remission stage (n=30). Twenty children without lung lesions severed as the control group.</p><p><b>RESULTS</b>The TNF-α, IL-6 and IL-10 levels in BALF were higher in children with MPP at acute stage than those in the control group (P<0.05). The levels of TNF-α and IL-6 in BALF at remission stage were reduced to the levels similar to the control group and were significantly lower than those at the acute stage in children with MPP. However, the levels of IL-10 in BALF remained at higher levels at remission stage in children with MPP.</p><p><b>CONCLUSIONS</b>The levels of TNF-α, IL-6 and IL-10 in BALF increase in children with MPP at acute stage, suggesting that the cytokines may be involved in the pathogenesis of MPP.</p>
Texto completo:
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Índice:
WPRIM
Assunto principal:
Pneumonia por Mycoplasma
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Líquido da Lavagem Broncoalveolar
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Interleucina-6
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Fator de Necrose Tumoral alfa
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Interleucina-10
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Alergia e Imunologia
Limite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2011
Tipo de documento:
Article