Role of cholinergic anti-inflammatory pathway in regulating host response and its interventional strategy for inflammatory diseases / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
; (6): 355-364, 2009.
Article
em En
| WPRIM
| ID: wpr-272963
Biblioteca responsável:
WPRO
ABSTRACT
The cholinergic anti-inflammatory pathway (CAP) is a neurophysiological mechanism that regulates the immune system. The CAP inhibits inflammation by suppressing cytokine synthesis via release of acetylcholine in organs of the reticuloendothelial system, including the lungs, spleen, liver, kidneys and gastrointestinal tract. Acetylcholine can interact with alpha7 nicotinic acetylcholine receptors (alpha7 nAchR) expressed by macrophages and other cytokine producing cells, down-regulate pro-inflammatory cytokine synthesis and prevent tissue damage. Herein is a review of the neurophysiological mechanism in which the CAP regulates inflammatory response, as well as its potential interventional strategy for inflammatory diseases.
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1
Índice:
WPRIM
Assunto principal:
Pancreatite
/
Farmacologia
/
Fisiologia
/
Choque Hemorrágico
/
Baço
/
Nervo Vago
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Traumatismo por Reperfusão
/
Acetilcolina
/
Receptores Nicotínicos
/
Receptores Muscarínicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Chinese Journal of Traumatology
Ano de publicação:
2009
Tipo de documento:
Article