Influence of apolipoprotein E gene polymorphism on the lipid regulation by xuezhikang capsule / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 688-691, 2009.
Article
em Zh
| WPRIM
| ID: wpr-273643
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the influence of apolipoprotein E (ApoE) gene polymorphism on the lipid metabolism regulatory effect of Xuezhikang Capsule (XZKC).</p><p><b>METHODS</b>ApoE polymorphism of 74 patients with hyperlipidemia was detected by gene sequencing method, and their plasma levels of total cholesterol (TC), triglyceride (TG), high- and low-density lipoprotein cholesterol (HDL-C and LDL-C) were determined before and after they received a 6-week treatment of XZKC, for analyzing the relationship between ApoE gene polymorphism and the changes of various blood lipids associated indices.</p><p><b>RESULTS</b>The effect of XZKC on reducing TG in the epsilon2 allele (E2/E2 and E2/E3 genotypes) was higher than that in the E3/E3 genotypes and epsilon4 allele (E3/E4 and E4/E4 genotypes), while on increasing HDL-C, it showed more effect in the epsilon4 allele (E3/E4 and E4/E4 genotypes) than that in the epsilon2 allele (E2/E2 and E2/E3 genotypes) and E3/E3 genotypes.</p><p><b>CONCLUSION</b>Patients' ApoE gene polymorphism could influence the lipid regulatory effect of XZKC, embodying mainly by raising HDL-C and reducing TG in patients with different ApoE genotypes to different extents.</p>
Texto completo:
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Índice:
WPRIM
Assunto principal:
Apolipoproteínas E
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Polimorfismo Genético
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Triglicerídeos
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Sangue
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Medicamentos de Ervas Chinesas
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Usos Terapêuticos
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Tratamento Farmacológico
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Metabolismo dos Lipídeos
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Genética
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Genótipo
Limite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Ano de publicação:
2009
Tipo de documento:
Article