Study on relationship of dose-effect and time-effect of APA microencapsulated bovine chromaffin cells on pain treatment / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 1145-1153, 2011.
Article
em Zh
| WPRIM
| ID: wpr-274937
Biblioteca responsável:
WPRO
ABSTRACT
This study was to investigate the relationship of dose-effect and time-effect of Alginate-Polylysine-Alginate (APA) microencapsulated bovine chromaffin cells on the treatment of pain model rats. Using a rat model of painful peripheral neuropathy, the antinociceptive effects of APA microencapsulated bovine cells transplanted into the subarachnoid space was evaluated by cold allodynia test and hot hyperalgesia test. Compared with control group, the withdrawal difference with cell number 50 thousands groups, 100 thousands groups and 200 thousands groups was reduced (P < 0.05), and the difference decreased with the cells increases, indicating a significant analgesic effect. There was no significant difference between 400 thousands groups and 200 thousands groups. This analgesic effect maintained longer than 12 weeks. There was a positive correlation between the analgesic effect and the quantity of APA microencapsulated bovine chromaffin cells which were transplanted to treat pain model rats, and the effective antinociception remained longer than 12 weeks.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Farmacologia
/
Polilisina
/
Ciática
/
Terapêutica
/
Transplante
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Células Cromafins
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Implantes Experimentais
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Relação Dose-Resposta a Droga
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Composição de Medicamentos
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Alginatos
Limite:
Animals
Idioma:
Zh
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2011
Tipo de documento:
Article