Studies on effects of aluminum compounds on aluminum contents in serum and brain of mice with high performance capillary electrophoresis / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the effects of alum, aluminum chloride and aluminum hydroxide on aluminum contents in serum and brain of mice with high performance capillary.</p><p><b>METHOD</b>60 days after the mice were given daily alum, aluminum chloride and aluminum hydroxide with the same aluminum content of 14.25, 57 mg x kg(-1) x d(-1), respectively, the aluminum content in serum and brain of mice were determined with high performance capillary chromatography.</p><p><b>RESULT</b>The average recoveries of serum aluminum determination was 96.5%-103%. The average recoveries of brain aluminum assay was 92.2%-105.3%. Except control group, serum aluminum increased obviously. Brain aluminum increased in all the large doses groups. 2 weeks after the mice were stopped being given these drugs, serum and brain aluminum recovered to normal level, except aluminum chloride large doses group.</p><p><b>CONCLUSION</b>The metabolism and excretion mechanism of aluminum in mice depends on the chemical states of the aluminum compound.</p>