HLA class I and II polymorphism and haplotypes in Guangdong Han population / 中华医学遗传学杂志
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
; (6): 467-469, 2005.
Article
em Zh
| WPRIM
| ID: wpr-280023
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the polymorphism and haplotypes of HLA class I and II in Guangdong Han population and detect the HLA-A, B, Cw and DRB1 allele frequencies.</p><p><b>METHODS</b>An auto semi-quantitative PCR-sequence speacific oligonucleotide probe(PCR-SSOP) method was adopted in exploring the HLA-A, B, Cw and DRB1 genotypes of the samples from 160 bone marrow donors.</p><p><b>RESULTS</b>Twelve HLA-A, 23 B, 11 Cw and 13 DRB1 alleles were obtained. A total of 9 HLA-A-B, 20 Cw-B, 7 A-Cw, and 8 A-DRB1, 9 B-DRB1, 10 Cw-DRB1 haplotypes were found.</p><p><b>CONCLUSION</b>HLA class I and II alleles in Guangdong Han population have plenty of polymorphisms. The haplotype distribution possesses territory characteristic.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Polimorfismo Genético
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Haplótipos
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Antígenos HLA-A
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Antígenos HLA-B
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Antígenos HLA-C
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Antígenos HLA-DR
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Desequilíbrio de Ligação
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China
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Povo Asiático
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Frequência do Gene
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
Zh
Revista:
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
Ano de publicação:
2005
Tipo de documento:
Article