Unrelated donor peripheral blood stem cell transplantation for hematologic malignancies / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 112-115, 2006.
Article
em Zh
| WPRIM
| ID: wpr-280722
Biblioteca responsável:
WPRO
ABSTRACT
This study was aimed to explore feasibility and efficacy of unrelated donor peripheral blood stem cell transplantation (UD-PBSCT) in treatment of hematologic malignancies. Ten patients with hematologic malignancies underwent high resolution DNA based typing HLA-matched or 1 locus mismatched UD-PBSCT. Busulfan, cyclophosphamide, Ara-C, MeCCNU and antithymocyte globulin (ATG) were used for preconditioning regimen in all cases. All patients received mycophenolate mofetile, cyclosporin A and short-term methotrexate with CD25 antibody as the graft-versus-host disease (GVHD) prophylaxis. The results showed that rapid engraftment was observed in all cases who presented full donor chimerism at 28 days post transplantation by STR-PCR. The median time of neutrophil recovery > 0.5 x 10(9)/L, platelet recovery > 20 x 10(9)/L was 13, 17.5 days respectively after transplantation. The incidence of acute GVHD was 3 cases (one case with grade I was recovered from GVHD by himself, one case with grade III was cured, one case with grade VI was died). It is concluded that above-mentioned preconditioning regimen and GVHD prophylaxis are effective approaches for unrelated donor peripheral blood stem cell transplantation in hematopoietic malignancies.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Terapêutica
/
Doadores de Sangue
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Transplante de Células-Tronco de Sangue Periférico
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Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Doença Enxerto-Hospedeiro
/
Métodos
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Ano de publicação:
2006
Tipo de documento:
Article