Effect of triptergium wilfordii polyglycosidium on content of Th1 and Th2 in child recurrent nephrotic syndrome / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 441-443, 2008.
Article
em Zh
| WPRIM
| ID: wpr-284463
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of triptergium wilfordii polyglycosidium on the content of Th1 and Th2 in the treatment child patients of rcurrent nephrotic syndrome.</p><p><b>METHOD</b>Patients were randomized into treatment group and health group. Sixty-one patients in treatment group were treated with triptergium wilfordii polyglycosidium 1 mg x kg(-1) x d(-1) orally tid for 12 weeks. However, patients in health group was not treated with any drugs. Twelve weeks constituted one course of treatment and the content of IL-12, IL-2, TNF-alpha, IL-13, IL-6, IL-4 in peripheral blood was measured before and behind therapy.</p><p><b>RESULT</b>In treatment group, the content of serum cytokines behind therapy was significantly lower than that before therapy, except for IL-12.</p><p><b>CONCLUSION</b>Triptergium wilfordii polyglycosidium could reduce the cytokine level (except for IL-12) of Th1 and Th2, which could lead a therapeutic effect of in the child patients of RNS.</p>
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Assunto principal:
Farmacologia
/
Medicamentos de Ervas Chinesas
/
Química
/
Interleucina-4
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Interleucina-2
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Fator de Necrose Tumoral alfa
/
Células Th2
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Células Th1
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Interleucina-13
/
Interleucina-12
Tipo de estudo:
Clinical_trials
Limite:
Child
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Female
/
Humans
/
Male
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2008
Tipo de documento:
Article