Correlation between the polymorphism of platelet glycoprotein GPIb α Kozak gene and transient ischemic attack / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>Genic susceptibility could increase the risk of transient ischemic attack (TIA). The objective of this study is to investigate the relationship between the polymorphism of platelet glycoprotein GPIb α Kozak gene and TIA in Qindao Han population.</p><p><b>METHODS</b>The polymorphisms of platelet glycoprotein GPIb α Kozak gene -5T/C in TIA patients and normal control were detected with sequence-specific primers polymerase chain reaction (PCR-SSP).</p><p><b>RESULTS</b>The prevalence of the CC genotype and C alleles were significantly higher in TIA patients than in the control group (P<0.05). The positive correlation between C allele and TIA was showed by logistic regression analysis (P=0.016).</p><p><b>CONCLUSION</b>The -5T/C polymorphism of the platelet glycoprotein GPIb α Kozak gene is implicated in the pathogenesis of TIA. C allele is an independent risk factor for TIA.</p>