The influence of N-acetyl-L-cysteine on pulmonary injury and oxygen stress after smoke inhalation injury / 中华烧伤杂志
Chinese Journal of Burns
; (6): 152-154, 2002.
Article
em Zh
| WPRIM
| ID: wpr-289222
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the influence of N-acetyl-L-cysteine (NAC) on pulmonary injury and oxygen stress caused by smoke inhalation injury.</p><p><b>METHODS</b>Rats inflicted with smoke inhalation injury were employed as the model. WBC in BALF (bronchoalveolar lavage fluid), MPO (myeloperoxidase) activity, hydrogen peroxide (H(2)O(2)) content, GSH (glutathione) content and total antioxidant (TAO) capacity in pulmonary tissue were determined.</p><p><b>RESULTS</b>Postinjury WBC in BALF, MPO activity in pulmonary tissue and H(2)O(2) content decreased obviously after NAC treatment. But the pulmonary tissue contents of GSH and ATO increased evidently after the treatment with NAC.</p><p><b>CONCLUSION</b>NAC treatment could ameliorate pulmonary oxygen stress after smoke inhalation injury. AS a result, the pulmonary antioxidant capacity was improved.</p>
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Índice:
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Assunto principal:
Patologia
/
Farmacologia
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Acetilcisteína
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Líquido da Lavagem Broncoalveolar
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Lesão por Inalação de Fumaça
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Sequestradores de Radicais Livres
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Ratos Wistar
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Peroxidase
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Estresse Oxidativo
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Modelos Animais de Doenças
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Burns
Ano de publicação:
2002
Tipo de documento:
Article