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Prognostic factors of resectable pulmonary metastases from colorectal cancer / 中华肿瘤杂志
Zhonghua zhong liu za zhi ; (12): 694-697, 2010.
Article em Zh | WPRIM | ID: wpr-293524
Biblioteca responsável: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the prognostic factors for patients who underwent curative resection of pulmonary metastases from colorectal cancer.</p><p><b>METHODS</b>The clinicopathological data of 60 patients with pulmonary metastases from colorectal carcinoma who underwent a radical pulmonary metastasectomy between February 1985 and December 2004 at the Cancer Hospital of Chinese Academy of Medical Sciences were retrospectively reviewed and analyzed.</p><p><b>RESULTS</b>The overall 5-year survival rate was 43.7% after pulmonary excision and 74.0% after colorectal resection. Three factors were identified as significant by univariate log-rank test for overall survival after pulmonary resection, they were preoperative carcinoembryonic antigen, number of pulmonary metastases (solitary vs. multiple), and hilar and/or mediastinal lymph node metastases (P < 0.05). Multivariate analysis showed that number of pulmonary metastases (solitary vs. multiple) and hilar and/or mediastinal lymph node metastasis were independent prognostic factors. However, shorter disease-free interval and more number of pulmonary metastases predicted poor prognosis after primary colorectal resection.</p><p><b>CONCLUSION</b>Pulmonary resection for metastases from colorectal cancer is safe and patients may get long-term survival in selected cases, especially in patients with a solitary pulmonary metastasis and without hilar and/or mediastinal lymph node metastasis.</p>
Assuntos
Texto completo: 1 Índice: WPRIM Assunto principal: Patologia / Pneumonectomia / Neoplasias Retais / Cirurgia Geral / Sangue / Antígeno Carcinoembrionário / Análise Multivariada / Taxa de Sobrevida / Estudos Retrospectivos / Seguimentos Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male Idioma: Zh Revista: Zhonghua zhong liu za zhi Ano de publicação: 2010 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Patologia / Pneumonectomia / Neoplasias Retais / Cirurgia Geral / Sangue / Antígeno Carcinoembrionário / Análise Multivariada / Taxa de Sobrevida / Estudos Retrospectivos / Seguimentos Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male Idioma: Zh Revista: Zhonghua zhong liu za zhi Ano de publicação: 2010 Tipo de documento: Article