Protective effect of Rheum tanguticum polysaccharides (RTP) on traumatic brain injury in rats / 中国中药杂志
Zhongguo Zhong Yao Za Zhi
; (24): 974-971, 2003.
Article
em Zh
| WPRIM
| ID: wpr-293674
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate protective effects of Rheum tanguticum polysaccharides (RTP) on traumatic brain injury (TBI) in rats.</p><p><b>METHOD</b>The polysaccharides (RTP) were extracted from Tanguficum Maxim. 120 rats were divided into 15 groups, with 8 rats in each group. RTP at 100, 200 and 400 mg x kg(-1) were administrated orally once a day for five days, and model of brain injury was made by dropping weight method.</p><p><b>RESULT</b>RTP reduced water content and malondialdehyde (MDA) levels, and increased total SOD activity and Na+-K+ ATPase activity after injuried.</p><p><b>CONCLUSION</b>The polysaccharides may be one of the effective comptents in Rheum tanguticum, showing significant neuroprotective effects.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Patologia
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Farmacologia
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Plantas Medicinais
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Polissacarídeos
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Rheum
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Superóxido Dismutase
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Lesões Encefálicas
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Córtex Cerebral
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Química
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Ratos Sprague-Dawley
Limite:
Animals
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Ano de publicação:
2003
Tipo de documento:
Article