Protective effects of Guangdong Liangcha grandes on restraint stress-induced liver damage in mice / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 664-669, 2008.
Article
em Zh
| WPRIM
| ID: wpr-295462
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of Guangdong Liangcha Keli on restraint stress-induced liver damage in mice.</p><p><b>METHOD</b>Thirty-five male C57BL/6J mice of 7 weeks old were divided into 5 groups randomly with 7 mice in each group normal group, restraint stress group, 250 mg kg(-1) Vitamin C, Guangdong Liangcha Keli 500 mg kg(-1) and 250 mg kg(-1). After 18 hr restraint stress, the ALT acitivity in plasma, MDA level in plasma and liver, GSH content, GSH-PX and GST activities, NO level and ORAC value in liver were determined.</p><p><b>RESULT</b>Compared with restraint model group, Guangdong Liangcha Keli could markedly reduce ALT activity (92.75 +/- 1.91 vs 39.29 +/- 2.56, 32.69 +/- 1.46) U L(-1), and protect the liver damage induced by oxidative stress. In addition, Guangdong Liangcha Keli could effectively increase the ORAC value, GSH content, GSH-PX activity and GST activity and reduce the MDA level and NO level in liver.</p><p><b>CONCLUSION</b>Oral treatment of Guangdong Liangcha Keli is found to reduce restraint stress-induced liver damage in terms of above mentioned biochemical parameters, and these protective effects may be related to its free radical scavenging activity and lipid peroxidation inhibitory effects.</p>
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Índice:
WPRIM
Assunto principal:
Patologia
/
Farmacologia
/
Estresse Psicológico
/
Sangue
/
Restrição Física
/
Medicamentos de Ervas Chinesas
/
Química
/
Estresse Oxidativo
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Alanina Transaminase
/
Glutationa
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2008
Tipo de documento:
Article