Distribution of HIV-1 subtype and prevalence of HIV-1 drug resistance in Liuzhou and Nanning / 病毒学报
Chinese Journal of Virology
; (6): 290-294, 2010.
Article
em Zh
| WPRIM
| ID: wpr-297868
Biblioteca responsável:
WPRO
ABSTRACT
To investigate HIV-1 subtype distribution and prevalence of HIV-1 drug resistance in Liuzhou and Nanning, a total of 304 HIV-infected subjects or AIDS patients from Liuzhou and Nanning were recruited. Whole blood was withdrawn from a peripheral vein of each subject. HIV RNA were extracted from plasma, and subjected to PCR amplification targeting HIV pol gene fragment and DNA sequencing. Sequences obtained were subtyped by phylogenetic analysis. Two subtypes, CRF01_AE and CRF07_BC, were found in subjects from Liuzhou, accounting for 75.2% and 24.8%, respectively. Subtype CRF01 AE, CRFO8_BC, B, and C were found in subjects from Nanning. CRF01_AE and CRF08 BC were still the dominant strains in Nanning, accounting for 85.8% and 11.5%, respectively. Sequences were also analyzed for drug resistance mutations, and rates of drug resistance were calculated. The rate of drug resistance was 3.3% in ART-naive subjects from Liuzhou, and 8.7% in the ART-experienced. For patients from Nanning, the rate was 1.4% in ART-naive subjects, and 27.5% in ART-experienced subjects.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Farmacologia
/
Filogenia
/
Virologia
/
Dados de Sequência Molecular
/
Infecções por HIV
/
China
/
Epidemiologia
/
HIV-1
/
Classificação
/
Fármacos Anti-HIV
Tipo de estudo:
Prevalence_studies
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Virology
Ano de publicação:
2010
Tipo de documento:
Article