Analysis of 993 cases of fetal malformations from 1999 to 2006 / 中国医学科学院学报

ABSTRACT

<p><b>OBJECTIVE</b>To study the value of prenatal ultrasound in the diagnosis of fetal malformations.</p><p><b>METHODS</b>We retrospectively analyzed the clinical data of 993 cases of neonates and induced babies with malformations who were labored in our hospital from January 1999 to October 2006.</p><p><b>RESULTS</b>The incidence rate of fetal malformation was 22.5 per thousand in our study group. The detection rate of prenatal ultrasound was 79.02% (1 062/1 344), among which the detection rate of the severe malformations (87.58%, 860/982) were significantly higher than that of the minor malformations (55.80%, 202/362) (P < 0.005). The false negative rate was high for the extremity malformations (39.46%) and facial malformations (31.91%), especially the acrosclerodermas, simple cleft palates, and ear deformities.</p><p><b>CONCLUSION</b>Prenatal ultrasound is sensitive for fetal severe malformations, while the detection rate is low for fetal minor malformations.</p>