Effects of Shenfu Injection () on cerebral metabolism in a porcine model of cardiac arrest / 中国结合医学杂志
Chin. j. integr. med
; Chin. j. integr. med;(12): 33-39, 2017.
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| ID: wpr-301038
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ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of Shenfu Injection (, SFI) on cerebral metabolism in a porcine model of cardiac arrest (CA).</p><p><b>METHODS</b>Thirty Wuzhishan minipigs were randomly assigned to the control group (n=6), epinephrine group (EP group, n=12) and Sfigroup (n=12). After 8 min of untreated ventricular fifibrillation (VF), pigs in the EP group or Sfigroup were administered with either EP (0.02 mg/kg) or Sfi(1.0 mL/kg), respectively. After successful resuscitation, cerebrospinal fluid (CSF) levels of glucose, pyruvate, lactate, glutamate and glycerol were measured at 1, 6, 12 and 24 h after recover from spontaneous circulation (ROSC). In addition, neurologic defificit score (NDS) was calculated at 24 h after ROSC. Surviving pigs were killed at 24 h after ROSC, and the brain tissue was obtained for ultra-microstructure examination.</p><p><b>RESULTS</b>Compared with the EP group, CSF glucose and pyruvate levels were higher (all P<0.01), and lactate levels were lower in the Sfigroup (P<0.01). Meanwhile, CSF glutamate and glycerol levels in the Sfigroup were lower in comparison to the EP group (all P<0.05). In addition, Sfidecreased NDS at 24 h after ROSC (P<0.01), and alleviated the histopathological damage of the brain.</p><p><b>CONCLUSIONS</b>Sficould alleviate brain injury after CA, which may be associated with improving cerebral metabolism.</p>
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Assunto principal:
Perfusão
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Farmacologia
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Circulação Sanguínea
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Gasometria
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Encéfalo
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Medicamentos de Ervas Chinesas
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Líquido Cefalorraquidiano
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Reanimação Cardiopulmonar
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Sus scrofa
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Usos Terapêuticos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Chin. j. integr. med
Ano de publicação:
2017
Tipo de documento:
Article