CTCF as a multifunctional protein in genome regulation and gene expression
Experimental & Molecular Medicine
; : e166-2015.
Article
em En
| WPRIM
| ID: wpr-30204
Biblioteca responsável:
WPRO
ABSTRACT
CCCTC-binding factor (CTCF) is a highly conserved zinc finger protein and is best known as a transcription factor. It can function as a transcriptional activator, a repressor or an insulator protein, blocking the communication between enhancers and promoters. CTCF can also recruit other transcription factors while bound to chromatin domain boundaries. The three-dimensional organization of the eukaryotic genome dictates its function, and CTCF serves as one of the core architectural proteins that help establish this organization. The mapping of CTCF-binding sites in diverse species has revealed that the genome is covered with CTCF-binding sites. Here we briefly describe the diverse roles of CTCF that contribute to genome organization and gene expression.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Ligação Proteica
/
Proteínas Repressoras
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Proteínas Cromossômicas não Histona
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Regulação da Expressão Gênica
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Genoma
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Proteínas de Ciclo Celular
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Mapas de Interação de Proteínas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2015
Tipo de documento:
Article