TET2 gene in hematological diseases / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 836-841, 2014.
Article
em Zh
| WPRIM
| ID: wpr-302389
Biblioteca responsável:
WPRO
ABSTRACT
The TET gene family has been found a few years ago. Recent studies indicated that TET2 (TET gene family 2) plays an important role in DNA demethylation, the epigenetic regulation and normal hematopoiesis. TET2 mutation has been discovered in a spectrum of myeloid malignancies, including myeloproliferative neoplasms (MPN), myelodysplastic syndrome (MDS) and leukemia, which suggest the role of TET2 as a tumor suppressor. In this review the recent results implicating TET2 in hematological malignancies are summarized, including regulatory functions of TET gene epigenetics, TET2 gene and hematopoietic regulation in bone marrow, TET2 gene and hematological disease(MPN, MDS, AML, CMML, lymphoma) and so on.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Medula Óssea
/
Regulação da Expressão Gênica
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Proteínas Proto-Oncogênicas
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Epigênese Genética
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Proteínas de Ligação a DNA
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Genética
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Doenças Hematológicas
/
Metabolismo
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Ano de publicação:
2014
Tipo de documento:
Article