Lipid peroxidation injury and endoplasmic reticulum stress in Al-induced apoptosis / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
; (12): 143-146, 2008.
Article
em Zh
| WPRIM
| ID: wpr-303989
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the role of lipid peroxidation injury and endoplasmic reticulum stress in Al-induced apoptosis.</p><p><b>METHODS</b>Neurons from 0-3 day rats were cultured and treated with different concentrations of AlCl3.6H2O. Morphologic changes of neurons and endoplasmic reticulum were observed under fluorescent and transmission electron microscope; activities of superoxide dismutase (SOD), malondialdehyde (MDA) and ATP enzymes were detected.</p><p><b>RESULTS</b>Typical morphologic changes in neurons apoptosis and endoplasmic reticulum were found under fluorescent and transmission electron microscope; SOD enzyme viability and ATP enzyme viability were significantly increased in the low-dosage group, but reduced in mid and high-dosage group (P < 0.01), whereas MDA levels decreased in the low-dosage group, but increased in mid and high-dosage group (P < 0.01).</p><p><b>CONCLUSION</b>Aluminum may induce neurons apoptosis, and lipid peroxidation injury in endoplasmic reticulum plays an important role in the apoptosis progression.</p>
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Índice:
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Assunto principal:
Patologia
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Fisiologia
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Peroxidação de Lipídeos
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Células Cultivadas
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Ratos Sprague-Dawley
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Apoptose
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Toxicidade
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Alumínio
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Estresse do Retículo Endoplasmático
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Metabolismo
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Ano de publicação:
2008
Tipo de documento:
Article