Pharmacokinetics of pueraria flavonoids from Pueraria lobata by anti-oxidant pharmacodynamics effect method / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2370-2373, 2007.
Article
em Zh
| WPRIM
| ID: wpr-307519
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the pharmacokinetics of pueraria flavonoids(PF) from Pueraria lobata.</p><p><b>METHOD</b>An anti-oxidant pharmacodynamics effect method was quoted to detect the antioxidant ability of PF contained in rats plasm after oral delivered, measures the fluorescence intensity, and calculates the concentration of components in plasma, then we can get the plot of the change of the content of PF contained in rats plasm, and then we can get the pharmacokinetics of Pueraria Flavonoids pellets.</p><p><b>RESULT</b>The AUC of Pueraria lobata isoflavone pellets is 4.40-fold of Yufengningxin tablets.</p><p><b>CONCLUSION</b>It can enhance the bioavailability of PF by made it to pellets.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Comprimidos
/
Flavonoides
/
Farmacocinética
/
Disponibilidade Biológica
/
Distribuição Aleatória
/
Química
/
Administração Oral
/
Ratos Wistar
/
Raízes de Plantas
/
Área Sob a Curva
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2007
Tipo de documento:
Article