Effects of quercetin on morphology and VEGF secretion of leukemia cells NB4 in vitro / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 25-27, 2006.
Article
em Zh
| WPRIM
| ID: wpr-308430
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of quercetin on cell morphology and VEGF expression of acute myeloblastic leukemia cells NB4 in vitro.</p><p><b>METHODS</b>The cytomorphology of NB4 cells was assessed by Wright-stain, apoptosis rate by apoptotic marker Annexin V, and VEGF secretion level by ELISA.</p><p><b>RESULTS</b>Typical apoptosis was found in NB4 cells after treatment with quercetin. Apoptotic marker Annexin V analysis showed that the apoptotic rate of NB4 cells was increased after treatment with quercetin. The secretion of VEGF of NB4 cells was significantly decreased after treatment with quercetin.</p><p><b>CONCLUSION</b>Quercetin can induce apoptosis and inhibit secretion of VEGF in NB4 leukemia cells.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Patologia
/
Farmacologia
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Quercetina
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Leucemia Mieloide Aguda
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Apoptose
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Secreções Corporais
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Linhagem Celular Tumoral
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Fator A de Crescimento do Endotélio Vascular
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Metabolismo
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Antineoplásicos Fitogênicos
Limite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Oncology
Ano de publicação:
2006
Tipo de documento:
Article