Kidney injury after cardiopulmonary bypass in infants with congenital heart disease / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 385-387, 2011.
Article
em Zh
| WPRIM
| ID: wpr-308783
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study kidney injury in infants with congenital heart disease (CHD) who underwent cardiac surgery with cardiopulmonary bypass (CPB).</p><p><b>METHODS</b>Forty CHD infants undergoing cardiac surgery with CPB from October 2009 to July 2010 were enrolled. The concentrations of serum tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), cystatin C (CysC) and urinary N-acetyl-beta-D-glucosaminidase (NAG) were detected using ELISA before bypass, at the end of surgery, and 2 hrs, 6 hrs and 24 hrs after surgery. Serum concentrations of creatinine (Cr) and urea nitrogen (BUN) were measured with conventional biochemistry technique before and after surgery.</p><p><b>RESULTS</b>The concentrations of serum Cr and BUN were normal before and after surgery. After CPB, the concentrations of serum TNF-α and IL-6 and urinary NAG increased significantly (P<0.05). Serum TNF-α was positively correlated with urinary NAG and serum CysC (r=0.195, 0.190, respectively; both P<0.05). Serum IL-6 was positively correlated with urinary NAG (r=0.278, P<0.01). The positive rate in kidney injury was detected by serum CysC and urinary NAG were significantly higher than by serum Cr or BUN (both P<0.01).</p><p><b>CONCLUSIONS</b>CPB can cause acute kidney injury in infants, which may be correlated with the increase in the concentrations of serum TNF-α and IL-6. Serum CysC and urinary NAG may be used as sensitive markers for reflecting the changes of renal function.</p>
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Índice:
WPRIM
Assunto principal:
Acetilglucosaminidase
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Cirurgia Geral
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Urina
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Sangue
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Ponte Cardiopulmonar
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Interleucina-6
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Fator de Necrose Tumoral alfa
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Cistatina C
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Injúria Renal Aguda
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Cardiopatias Congênitas
Limite:
Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2011
Tipo de documento:
Article