Experimental varicocele affects the ipsilateral testis in rats / 中华男科学杂志
National Journal of Andrology
; (12): 805-809, 2008.
Article
em Zh
| WPRIM
| ID: wpr-309790
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the impact of experimental varicocele (EV) on the ipsilateral testis in rats.</p><p><b>METHODS</b>EV was induced by partial ligation of the left renal vein in male SD rats, the control rats subjected to sham operation, and the testes of the EV models and controls were extirpated 6, 12, and 18 weeks later. Johnson's score, ultrastructure of seminiferous tubules, intratesticular testosterone concentration (ITC) and germ cell apoptotic index (AI) of each left testis were evaluated.</p><p><b>RESULTS</b>Johnson's scores were (6.92 +/- 0.52), (4.83 +/- 0.41) and (2.95 +/- 0.26), ITCswere (6.32 +/- 0.85), (5.17 +/- 0.76) and (4.11 +/- 0.69) and AIs were (5.32 +/- 1.23), (15.21 +/- 0.97) and (21.13 +/- 1.12) respectively in the 6 w , 12 w and 18 w EV groups, significantly lower than in the corresponding control groups, (9.56 +/- 0.35, 9.63 +/- 0.31, 9.39 +/- 0.46), (9.64 +/- 1.23, 9.38 +/- 0.69, 9.73 +/- 0.49) and (3.21 +/- 1.15, 3.43 +/- 1.21, 3.61 +/- 1. 15) (P < 0.05), the former two showing a gradual decline while the latter a significant elevation with the increasing duration of varicocele. The damage to the ultrastructure of seminiferous tubules was aggravated with the prolonging of varicocele.</p><p><b>CONCLUSION</b>EV can cause a progressive decline of ITC, dyszoospermia and increased AI of germ cells.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Epitélio Seminífero
/
Testículo
/
Testosterona
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Varicocele
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Química
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Ratos Sprague-Dawley
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Apoptose
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Biologia Celular
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Modelos Animais de Doenças
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Infertilidade Masculina
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
National Journal of Andrology
Ano de publicação:
2008
Tipo de documento:
Article