Association between SNPs in SOD2 and noise-induced hearing loss / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
; (12): 211-214, 2009.
Article
em Zh
| WPRIM
| ID: wpr-311298
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the association between SNPs in SOD2 and noise-induced hearing loss in Chinese Han population.</p><p><b>METHODS</b>A case-control study was designed to study the effect of environmental risk factors on susceptibility to NIHL in 201 sensitive workers and 202 resistant workers. A questionnaire was designed to carry out an investigation, and an occupational health survey was used to identify the occupational risk factors. Genomic DNA was extracted from peripheral blood cells samples using standard procedures of Qiagen kit. SNPs were detected using standard procedures of TaqMan probe allele identification method.</p><p><b>RESULTS</b>In SOD2 gene, the C allele of rs4880 was a risk factor of NIHL, compared with the T allele, OR = 1.76, 95% CI 1.17 approximately 2.63, P = 0.006. CC and CT genotypes compared with TT were risk factors, crude OR = 2.24, 95% CI 1.43 approximately 3.50 and adjusted OR = 2.45, 95% CI 1.51 approximately 3.96, P < 0.001, respectively.</p><p><b>CONCLUSION</b>In Chinese Han population, SOD2 rs4880 SNP in the mitochondrial targeting sequence is associated with noise induced hearing loss.</p>
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Índice:
WPRIM
Assunto principal:
Superóxido Dismutase
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Estudos de Casos e Controles
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China
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Predisposição Genética para Doença
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Polimorfismo de Nucleotídeo Único
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Genética
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Perda Auditiva Provocada por Ruído
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Ruído Ocupacional
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
País/Região como assunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Ano de publicação:
2009
Tipo de documento:
Article