RNAi: antiviral therapy against dengue virus
Asian Pacific Journal of Tropical Biomedicine
;
(12): 232-236, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-312421
ABSTRACT
Dengue virus infection has become a global threat affecting around 100 countries in the world. Currently, there is no licensed antiviral agent available against dengue. Thus, there is a strong need to develop therapeutic strategies that can tackle this life threatening disease. RNA interference is an important and effective gene silencing process which degrades targeted RNA by a sequence specific process. Several studies have been conducted during the last decade to evaluate the efficiency of siRNA in inhibiting dengue virus replication. This review summarizes siRNAs as a therapeutic approach against dengue virus serotypes and concludes that siRNAs against virus and host genes can be next generation treatment of dengue virus infection.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Terapêutica
/
Dengue
/
Vírus da Dengue
/
RNA Interferente Pequeno
/
Interferência de RNA
/
Usos Terapêuticos
/
Genética
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Asian Pacific Journal of Tropical Biomedicine
Ano de publicação:
2013
Tipo de documento:
Artigo
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