Value of different biochemical markers in early diagnosis of acute myocardial infarction / 南方医科大学学报
Journal of Southern Medical University
; (12): 1347-1350, 2014.
Article
em Zh
| WPRIM
| ID: wpr-312574
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the value of the biochemical markers heart fatty acid binding protein (H-FABP), creatine kinase isoenzyme-MB (CK-MB), myocardial troponin T (cTnT) in early diagnosis of acute myocardial infarction (AMI).</p><p><b>METHODS</b>Serum levels of H-FABP, CK-MB, and cTNT were detected in 95 patients with confirmed AMI at different time points following the onset in comparison with the data from 43 patients without AMI. The sensitivity and specificity of H-FABP in different phases following the onset were compared between those of CK-MB and cTnT.</p><p><b>RESULTS</b>Serum H-FABP activities increased significantly within 3 h after the onset of AMI (P<0.01) and continued to increase at 3-6 h and 6-12 h (P<0.001). Serum level of CK-MB within 6 h and cTnT level within 3 h after AMI onset did not show obvious changes (P<0.05). Both the diagnostic sensitivity and specificity of H-FABP within 3 h and within 3-6 h were higher than those CK-MB and cTnT (P<0.05).</p><p><b>CONCLUSION</b>H-FABP is superior to CK-MB and cTnT in early diagnosis (within 3 h and 3-6 h following the onset) of AMI.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Sangue
/
Biomarcadores
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Doença Aguda
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Sensibilidade e Especificidade
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Troponina T
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Diagnóstico Precoce
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Diagnóstico
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Creatina Quinase Forma MB
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Proteínas de Ligação a Ácido Graxo
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Proteína 3 Ligante de Ácido Graxo
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Southern Medical University
Ano de publicação:
2014
Tipo de documento:
Article