Effect of HMME-PDT on hyperplastic scar in rabbit ear model / 中华整形外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the effect of HMME-PDT (Hematoporphyrin Monomethyl Ether-Photodynamic therapy) on Hyperplastic scar in the rabbit ear.</p><p><b>METHODS</b>The acute model of dermal Hyperplastic scar in the rabbit ear was established. 24 scars were randomly divided into 2 groups: the experimental group (n = 12) received HMME-PDT treatment, and the controlled group (n = 12) received no special treatment. Specimens were harvested from scars on postoperative 28 day. Scar hyper plasty and collagen fibers were observed by haematoxylin-eosin staining and Van-Gieson staining respectively. The microvessel density was calculated under microscope.</p><p><b>RESULTS</b>Compared with the controlled group, HMME-PDT treatment in the experimental group reduced scar formation, decreased the microvessel density and prevented excess collagen deposition at the wound site.</p><p><b>CONCLUSIONS</b>HMME-PDT may play a role in inhibiting hyperplastic scar in rabbit ear.</p>