Expression profile of miRNAs in APP swe/PSΔE9 transgenic mice / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To observe the changes of miRNA expression profiles in APPswe/PS&delta;E9 transgenic mice and explore the possible roles of miRNA in the pathogenesis of Alzheimer's disease.</p><p><b>METHODS</b>Using miRNA chip technique, we examined the miRNA expression in the brain tissue of 6-month-old APPswe/PS&delta;E9 transgenic mice, with age-matched wild-type mice as the control group.</p><p><b>RESULTS</b>Twelve miRNAs showed differential expressions by more than two folds in APPswe/PS&delta;E9 transgenic mice, namely miRNA-135a, miRNA-135a-2*, miRNA-298, miRNA-466b-3p, miR-669-3p, miR-142-5p, miR-144, miR-466f-3p, miR-466g, miR-200a, miR-200b and miR-96. Five miRNAs were significantly down-regulated in the transgenic mice, including miRNA-135a, miRNA-135a-2*, miRNA-298, miRNA-466b-3p, and miR-669-3p.</p><p><b>CONCLUSION</b>The 5 down- regulated miRNA may play important roles in the pathogenesis of AD in APPswe/PS&delta;E9 transgenic mice.</p>