Expression and significance of integrin alpha5, beta1 and E-CD in patients with non-small cell lung carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 746-749, 2006.
Article
em Zh
| WPRIM
| ID: wpr-316311
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between the expressions of integrin alpha5 beta1 and E-CD, and clinicopathological characteristics and prognosis of patients with non-small cell lung carcinoma (NSCLC).</p><p><b>METHODS</b>The expression of integrin alpha5 beta1 and E-CD were analyzed in 53 NSCLC and 12 control specimens by immunohistochemical assay.</p><p><b>RESULTS</b>The expression of integrin alpha5 beta1 was significantly higher in NSCLC (58.5%) than that in normal lung tissue (16.7%), and also positively related with pathological characteristics (P = 0.021), lymph node metastasis (P = 0.006), and clinical stage (P = 0.002). The 3-year survival rate in NSCLC group was significantly lower than that in control group (22.3% vs 40.6% , P = 0.041). The positive expression of E-CD in NSCLC and control group was 32.1% and 91.7%, respectively, and negatively correlated with pathological characteristics (P = 0.010) and lymph node metastasis (P = 0.002). The 3-year survival rate in control group was 19.9%, lower than that in NSCLC group (41.2%, P > 0.05), but the difference is not significant.</p><p><b>CONCLUSION</b>The overexpression of integrin alpha5 beta1 may contribute to lymph node metastasis and play an inverse role, while E-CD may be a beneficial prognostic factor in patients with NSCLC.</p>
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Índice:
WPRIM
Assunto principal:
Patologia
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Imuno-Histoquímica
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Fumar
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Caderinas
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Análise de Sobrevida
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Carcinoma Pulmonar de Células não Pequenas
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Integrina alfa5beta1
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Neoplasias Pulmonares
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Metástase Linfática
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Metabolismo
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Oncology
Ano de publicação:
2006
Tipo de documento:
Article